Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use

本发明涉及通式I包含全氟烷基和糖基的络合物：其中R代表通过1-OH位置或者1-SH位置连接的单糖或者寡糖基；R#-[f]是全氟碳链，K是金属络合物，而Y和z是连接基团。根据本发明的化合物适合于静脉淋巴造影、肿瘤诊断以及梗塞和坏死的成像。 The invention relates to perfluoroalkyl-containing complexes comprising sugar residues of the general formula (I), wherein R represents a mono- or oligosaccharide residue bound in t...

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Bibliographische Detailangaben
Hauptverfasser:	NIEDBALLA ULRICH, PLATZEK JOHANNES, MARESKI PETER
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	本发明涉及通式I包含全氟烷基和糖基的络合物：其中R代表通过1-OH位置或者1-SH位置连接的单糖或者寡糖基；R#-[f]是全氟碳链，K是金属络合物，而Y和z是连接基团。根据本发明的化合物适合于静脉淋巴造影、肿瘤诊断以及梗塞和坏死的成像。 The invention relates to perfluoroalkyl-containing complexes comprising sugar residues of the general formula (I), wherein R represents a mono- or oligosaccharide residue bound in the 1-OH or 1-SH position, Rf represents a perfluorated carbon chain, K is a metal complex and Y and Z are linker groups. The inventive complexes are suitable for use in intravenous lymphography, in tumor diagnosis and for infarct and necrosis imaging.