Crystalline base of citalopram

Crystalline citalopram base as well as citalopram hydrochloride and hydrobromide with a purity above 99.8% (wt./wt.), especially above 99.9% (wt./wt.) are new. Independent claims are also included for: (A) the production of a citalopram salt comprising: (a) liberation of citalopram base and precipit...

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Bibliographische Detailangaben
Hauptverfasser:	H. PETERSEN, K.P. BOGESO, P. HOLM
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BABY COMFORTERS CHEMISTRY CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR RECEIVING SPITTLE DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Crystalline citalopram base as well as citalopram hydrochloride and hydrobromide with a purity above 99.8% (wt./wt.), especially above 99.9% (wt./wt.) are new. Independent claims are also included for: (A) the production of a citalopram salt comprising: (a) liberation of citalopram base and precipitation of the liberated base in crystalline form; (b) optional recrystallisation of the crystalline base; and (c) conversion of the crystalline base into a salt; and (B) the production of citalopram base or a citalopram salt comprising (i) removal of one or more impurities of formula (I) from a crude citalopram mixture or a crude citalopram salt by precipitation of crystalline citalopram base; and (ii) optional recrystallisation and/or conversion into a salt. [Image] Z : halo; -O-SO 2-(CF 2) n-CF 3; -CHO; -NHR 1>; -COOR 2>; or -CONR 2>R 3>; n : 0-8; R 1>H or alkylcarbonyl; R 2>and R 3>H; alkyl; optionally substituted aryl; or aralkyl. ACTIVITY : Antidepressant. MECHANISM OF ACTION : Serotonin re-uptake inhibitor.