Technique for synthesizing Irbesartan
A process for synthesizing Ebeishatan features that the intermediate 2-n-butyl-3-[(2'-cyanobiphenyl-4- yl)methyl]-1,3-diazaspiro [4,4]-nonyl-1-ene-4-one can be directly used in next step without purification, and in the reaction where cyano is converted to tetrazazole, the mixture of tributyl t...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | A process for synthesizing Ebeishatan features that the intermediate 2-n-butyl-3-[(2'-cyanobiphenyl-4- yl)methyl]-1,3-diazaspiro [4,4]-nonyl-1-ene-4-one can be directly used in next step without purification, and in the reaction where cyano is converted to tetrazazole, the mixture of tributyl tin chloride and sodium azide is used to replace tributyl tin azide. Its advantage is high output rate upto 75%. |
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