Immunotherapeutic combinations for the treatment of tumours that overexpress gangliosides

Composition (A) for immunotherapy of tumors that overexpress gangliosides (I) comprises at least two of: (a) idiotypic vaccine containing anti-ganglioside antibody (Ab1); (b) idiotypic vaccine containing anti-idiotypic antibody (Ab2) specifically directed against a monoclonal anti-ganglioside antibo...

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Bibliographische Detailangaben
1. Verfasser:	L.E. FERNANDEZ MOLINA,A.M. VAZQUEZ LOPEZ,R. PREZRODR IGUEZ
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Composition (A) for immunotherapy of tumors that overexpress gangliosides (I) comprises at least two of: (a) idiotypic vaccine containing anti-ganglioside antibody (Ab1); (b) idiotypic vaccine containing anti-idiotypic antibody (Ab2) specifically directed against a monoclonal anti-ganglioside antibody; and (c) vaccine containing (I). ACTIVITY : Cytostatic; Immunostimulant. Male mice were immunized subcutaneously with 4 doses of the 1E10 anti-idiotypic antibody (50 Microg, days 0, 14, 28 and 42) on alumina gel, and intramuscularly with the ganglioside GM3-VSSP (120 Microg, days 7, 21, 35 and 49) on Montanide ISA51. On day 63, the animals were inoculated subcutaneously with 10 4> B16 murine tumor cells. Treatment was 1E10 alone did not slow tumor growth (tumor size after 31 days, about 12 units); GM3-VSSP alone did slow growth (size about 4.5 units) but the combination of both was most effective (size about 1.5 units). MECHANISM OF ACTION : Induction of a specific immune response, both humoral and cellular; Vaccine.