Oligopeptide suppressor of matrix metalloprotease 2

The present invention discloses an amino acid sequence of oligopeptide inhibitor of matrix metalloprotease 2 and a group of oligopeptides with matrix metalloprotease 2 conjunction activity, belonging to the field of biological medicine. On the basis of catalyzed zone MCD in which the matrix metallop...

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Bibliographische Detailangaben
1. Verfasser:	QINGMING,GAO WANG
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention discloses an amino acid sequence of oligopeptide inhibitor of matrix metalloprotease 2 and a group of oligopeptides with matrix metalloprotease 2 conjunction activity, belonging to the field of biological medicine. On the basis of catalyzed zone MCD in which the matrix metalloprotease-2 (MMP-2) is expressed and purified said invention uses the MCD as target to screen the phage random cycloheptapeptide library and dodecapeptide library so as to obtain a kind of oligopeptide capable of inhibiting matrix metalloprotease 2 hydrolysis activity, and said oligopeptide has the activity for inhibiting external infestation of tumor cell. These oligopeptides have the potential application value for targeted therapy of tumor and inhibiting tumor angiogenesis.