Process for the preparation of clopidogrel

A process for the preparation of clopidogrel (1) by reaction of the N,N'-bis-4,5,6,7-tetrahydro-[3,2-c]-thienopyridyl methane (12) with (R)-2-chlorophenylacetic acid derivatives of formula (13) in which X and R have the meanings as indicated in the disclosure.

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1. Verfasser: CASTALDI GRAZIANO,BARRECA GIUSEPPE,BOLOGNA ALBERTO
Format: Patent
Sprache:eng
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Zusammenfassung:A process for the preparation of clopidogrel (1) by reaction of the N,N'-bis-4,5,6,7-tetrahydro-[3,2-c]-thienopyridyl methane (12) with (R)-2-chlorophenylacetic acid derivatives of formula (13) in which X and R have the meanings as indicated in the disclosure.