Enzymatic deprotection of amines and hydroxides

Provided is a method of deprotecting a hydroxide or amine protected with a group of formulawhere the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provide...

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Bibliographische Detailangaben
1. Verfasser: R. PATEL,D. BRZOZOWSKI,V. B. NANDURI
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided is a method of deprotecting a hydroxide or amine protected with a group of formulawhere the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.