Benzamidine derivatives and use thereof as medicaments with LTB4-antagonistic effect

Benzamidine derivatives of formula (I), and their salts, are new: A =O(2-4C alkylene)O or (1-3C alkylene)O; R1 = 1-6C alkyl or halo; R2 = H, 1-6C alkyl or halo; R3, R4 = H, 1-6C alkyl, 1-6C alkoxy, OH, CF3; or R3+R4 = part of a condensed benzene ring (which may be substituted by OH, 1-4C alkyl or 1-...

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Hauptverfasser:	ERNST-OTTO RENTH, RALF ANDERSKEWITZ, KURT SCHROMM
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	Benzamidine derivatives of formula (I), and their salts, are new: A =O(2-4C alkylene)O or (1-3C alkylene)O; R1 = 1-6C alkyl or halo; R2 = H, 1-6C alkyl or halo; R3, R4 = H, 1-6C alkyl, 1-6C alkoxy, OH, CF3; or R3+R4 = part of a condensed benzene ring (which may be substituted by OH, 1-4C alkyl or 1-4C alkoxy); R5 = H, aryl, preferably Ph, OPh, CR7R8, COPh or CH(OH) (where the Ph ring may be substituted by OH or 1-4C alkoxy), or C(O)NR9R10; R6 = H, 1-6C alkoxycarbonyl or 1-6C acyl; and R7-R10 = H or 1-8C alkyl.