Non-toxic immunogens derived from a retroviral regulatory protein, antibodies, preparation method therefor and pharmaceutical compositions containing same

An immunogenic compound that, being non-toxic, may be administered to humans, and is derived from an HIV-1, HIV-2, HTLV-1 or HTLV-2 virus regulatory protein by chemical processing using a coupling agent such as an aldehyde, or from a carrier protein activated by pre-processing using an aldehyde, whe...

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Bibliographische Detailangaben
1. Verfasser:	J. F. ZAGURY,B. BIZZINI,D. ZAGURY
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An immunogenic compound that, being non-toxic, may be administered to humans, and is derived from an HIV-1, HIV-2, HTLV-1 or HTLV-2 virus regulatory protein by chemical processing using a coupling agent such as an aldehyde, or from a carrier protein activated by pre-processing using an aldehyde, whereby said compound may be recognised by antibodies to said regulatory protein, and retain sufficient immunogenic properties to produce antibodies that neutralise or block the native protein, while losing at least 50 % of the toxic biological properties of said native protein.