Benzoxazinone dopamine D4 receptor antagonists

Compounds having formulae (I) or (II) wherein R and R are independently hydrogen or C1-C6 alkyl; X is N or CH; and R is phenyl, naphthyl, heteroaryl, substituted phenyl, substituted naphthyl or substituted heteroaryl, wherein each substituent is independently selected from halogen, C1-C6 alkoxy, C1-...

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Hauptverfasser:	L. D. WISE, T. BELLIOTTI, D. J. WUSTROW
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds having formulae (I) or (II) wherein R and R are independently hydrogen or C1-C6 alkyl; X is N or CH; and R is phenyl, naphthyl, heteroaryl, substituted phenyl, substituted naphthyl or substituted heteroaryl, wherein each substituent is independently selected from halogen, C1-C6 alkoxy, C1-C6 alkyl, -CN, -CF3, or sulphonamido, and the pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, are antagonists of dopamine D4 receptors.