24-homo-26,27-hexafluoro-choleccalciferols

The invention relates to a compound of formula (I) wherein A is a carbon double bond having the stereochemical configuration E or Z, i.e. of formula (a) or (b), respectively, R is hydroxy and R is hydrogen or =CH2 or R is hydrogen or fluoro and R is =CH2. Compounds of formula (I) induce differentiat...

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Bibliographische Detailangaben
Hauptverfasser:	J. A. IACOBELLI, M. R. USKOKOVIS
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a compound of formula (I) wherein A is a carbon double bond having the stereochemical configuration E or Z, i.e. of formula (a) or (b), respectively, R is hydroxy and R is hydrogen or =CH2 or R is hydrogen or fluoro and R is =CH2. Compounds of formula (I) induce differentiation and inhibition of proliferation in certain skin and cancer cell lines. Accordingly, the compounds of formula (I) are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis. Compounds of formula (I) are also useful as agents for the treatment of neoplastic diseases, such as leukemia.