Peptide derivatives

Peptide derivatives

Compounds represented by the following general formula and salts thereof; Y-L-Tyr-Q-NR -CH(R )-CO-X, wherein R represents hydrogen or C1-6 alkyl; R represents optionally substituted benzyl; Q represents D- or L-Arg; Y represents two hydrogen atoms of N-terminal amino group of L-Tyr, or one or two fu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: OKAYAMA TORU, SAKURADA SHINOBU, NUKUI ERIKO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compounds represented by the following general formula and salts thereof; Y-L-Tyr-Q-NR -CH(R )-CO-X, wherein R represents hydrogen or C1-6 alkyl; R represents optionally substituted benzyl; Q represents D- or L-Arg; Y represents two hydrogen atoms of N-terminal amino group of L-Tyr, or one or two functional groups substituting for the hydrogen atoms, for example, a C1-6 alkyl optionally having amino or carboxy; and X represents N-methyl- beta -alanine and other. The compounds have analgesic effect and can be used for the treatment of cancer pain or the like.