Consumption of activated hepatic stellate cells (HSC) and uses thereof

A binding molecule comprising a binding domain that binds to an antigen expressed on activated hepatic stellate cells (HSCs) and a functional domain that is capable of enhancing antibody effector function, such as antibody dependent cell mediated cytotoxicity (ADCC) against activated HSCs. Also prov...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG MINHUA, ZHANG RUIPENG, LU CHRIS XIANGYANG, GU, XIANGJU, JUSTIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A binding molecule comprising a binding domain that binds to an antigen expressed on activated hepatic stellate cells (HSCs) and a functional domain that is capable of enhancing antibody effector function, such as antibody dependent cell mediated cytotoxicity (ADCC) against activated HSCs. Also provided herein are uses of such binding molecules. 一种包含结合结构域和功能结构域的结合分子，该结合结构域与在活化的肝星状细胞(HSC)上表达的抗原结合，该功能结构域能够增强抗体效应子功能，诸如针对活化的HSC的抗体依赖性细胞介导的细胞毒性(ADCC)。本文还提供了此类结合分子的用途。