Agents and methods for targeted delivery of nucleic acids to cells

The present invention relates to agents and methods for targeted delivery of nucleic acids to cells. In some embodiments, the nucleic acid payload comprises a nucleic acid encoding an antigen receptor, such as a T cell receptor (TCR) or a chimeric antigen receptor (CAR). The agents and methods described herein for targeted delivery of nucleic acids encoding antigen receptors can be used to produce immune effector cells genetically modified to express antigen receptors in vitro/ex vivo or in vivo. 本发明涉及用于靶向递送核酸至细胞的药剂和方法。在一些实施方案中，核酸有效载荷包含编码抗原受体(如T细胞受体(TCR)或嵌合抗原受体(CAR))的核酸。本文描述的用于靶向递送编码抗原受体的核酸的药剂和方法可用于体外/离体或体内产生经遗传修饰以表达抗原受体的免疫效应细胞。