TAT-PEG-PLGA coated manganese-doped silicon dioxide drug-loaded nanoparticles as well as preparation and application thereof

The invention relates to a TAT-PEG-PLGA coated manganese-doped silicon dioxide drug-loaded nanoparticle. The TAT-PEG-PLGA is used for coating the surface of manganese-doped silicon dioxide; wherein TAT is a cell permeable peptide, PEG is polyethylene glycol, and PLGA is a polylactic acid-glycolic acid copolymer; the structure of the TAT-PEG-PLGA is that TAT is connected to PLGA through PEG (Polyethylene Glycol). Through modification of TAT-PEG-PLGA on the surfaces of the nanoparticles, the nanoparticles have relatively high cell uptake efficiency on various tumors, and have relatively high mechanical strength and drug release control capability. The invention also provides a preparation method of the nano-particles, which comprises the following steps: firstly, synthesizing mesoporous silicon dioxide nano-spheres, and then doping manganese into silicon dioxide, so that part of silicon dioxide is converted into manganese orthosilicate, and meanwhile, a non-hollow structure in the mesoporous silicon dioxide nan