Novel compounds and their use to inhibit checkpoint kinase 2

The present invention provides a novel compound, its use for inhibiting checkpoint kinase 2 (Chk2), and its use for preventing or treating cancer. Since the compound of the present invention has high Chk2 selectivity, the compound can overcome the drug resistance and toxicity of PARP inhibitors and can be effectively used in the prevention or treatment of cancer. 本发明提供了一种新化合物、其用于抑制检查点激酶2(Chk2)的用途、及其用于预防或治疗癌症的用途。由于本发明的化合物具有高Chk2选择性，所述化合物可以克服PARP抑制剂的耐药性和毒性，并且可以有效用于预防或治疗癌症。