Anti-CD137 antigen binding molecules and uses thereof

The purpose of the present disclosure is to provide an anti-CD137 antigen-binding molecule having an immune cell activating effect, cytotoxic activity, or antitumor activity while hardly affecting non-tumor tissues such as normal tissues and having less side effects, and a method of using the same. CD137 antigen-binding molecules exhibiting an alteration in CD137 binding activity depending on various substances (e.g., low molecular weight compounds) in a target tissue are provided, and the molecules are prepared, having immune cell activation, cytotoxic activity, or anti-tumor activity, meanwhile, non-tumor tissues such as normal tissues and the like are hardly influenced, and the anti-CD137 antigen binding molecule has less side effects. Methods of using the anti-CD137 antigen binding molecules, pharmaceutical formulations, and the like are also provided. The present disclosure also provides antigen-binding molecules that exhibit altered antigen-binding activity depending on low molecular weight compounds, m