Synthesis method of ionizable lipid and preparation method and application of nucleic acid delivery system of ionizable lipid

The invention discloses a synthesis method of ionizable lipoids and a preparation method and application of a nucleic acid delivery system of the ionizable lipoids, the ionizable lipoids comprise ionizable lipoids containing fluorocarbon chains and ionizable lipoids containing hydrocarbon chains, and the ionizable lipoids containing the fluorocarbon chains are hydrophobic and lipophobic compounds. According to the present invention, the fluorinated lipid or polymer has characteristics of high surface activity, high stability and easy self-assembly, can provide high transfection efficiency when used for transfection of various cell lines, has excellent delivery efficiency, can form the more stable nanoparticles through the fluorinated lipid or polymer, can prevent degradation of the packaged biological product, can prolong the blood circulation time, and can provide the good transfection effect. A stable and efficient nucleic acid delivery system can be further prepared. Compared with a single ionizable lipid