K-5a2 solid dispersion, preparation method thereof and application of K-5a2 solid dispersion in preparation
The invention belongs to the technical field of preparation of pharmaceutical preparations, and particularly relates to a K-5a2 solid dispersion, a preparation method thereof and application of the K-5a2 solid dispersion in the aspect of preparations. The K-5a2 solid dispersion is prepared from the...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention belongs to the technical field of preparation of pharmaceutical preparations, and particularly relates to a K-5a2 solid dispersion, a preparation method thereof and application of the K-5a2 solid dispersion in the aspect of preparations. The K-5a2 solid dispersion is prepared from the following raw materials: K-5a2, a carrier, 4.5 to 9 parts of a diluent, an antioxidant and an organic solvent. The preparation method comprises the following steps: dissolving K-5a2 and the antioxidant in an organic solvent, firstly adding the carrier, then adding the diluent, and drying twice to obtain the K-5a2 solid dispersion. According to the application of the K-5a2 solid dispersion in the aspect of preparation, the K-5a2 solid dispersion is prepared into one of a K-5a2 tablet, a K-5a2 capsule and a K-5a2 dry suspension. The K-5a2 solid dispersion provided by the invention is used for preparing tablets, capsules and dry suspensions, the water solubility is good, the bioavailability is high, and the invention |
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