Cas12a nicking enzymes

The invention relates to the field of gene genome editing. In particular, the present invention relates to the provision of a Cas12a enzyme having nicking enzyme activity, as well as means and methods for modifying a genomic locus of interest with a Cas12a enzyme having nicking enzyme activity, and...

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Bibliographische Detailangaben
Hauptverfasser:	LEUTINE MICHAEL J, DE FLEISHAUWER DANIEL, VILLEGAS WARREN RAFAEL, D HALLUIN KATELIJN, MEULEWAETER, FRANK, NG WAN YEE, VAN DER OOST JOHN, STAALS ROBERT HENRICUS JOHANNES
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the field of gene genome editing. In particular, the present invention relates to the provision of a Cas12a enzyme having nicking enzyme activity, as well as means and methods for modifying a genomic locus of interest with a Cas12a enzyme having nicking enzyme activity, and uses thereof. 本发明涉及基因基因组编辑领域。特别地，本发明涉及提供具有切口酶活性的Cas12a酶，以及用于用具有切口酶活性的Cas12a酶修饰目的基因组基因座的方式和方法，及其用途。