Antibody capable of specifically recognizing 4-1BB as well as preparation method and application thereof

The invention discloses an antibody for specifically recognizing 4-1BB as well as a preparation method and application thereof. The antibody comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, the light chain va...

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Bibliographische Detailangaben
Hauptverfasser:	LI SHUANGQI, YAN XINTIAN, ZHOU YUNHUA, LANG GUOJUN, FU ZIBO, TAN YONGCONG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses an antibody for specifically recognizing 4-1BB as well as a preparation method and application thereof. The antibody comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, the light chain variable region comprises LCDR1, LCDR2 and LCDR3, and the sequence information of the antibody is shown in a sequence table. The antibody prepared by the invention has better appetency, better effect of inhibiting tumor growth in vivo and smaller toxic and side effects. 本发明公开了一种特异性识别4-1BB的抗体、其制备方法及其用途。所述抗体包含重链可变区和轻链可变区，所述重链可变区包含HCDR1、HCDR2和HCDR3，所述轻链可变区包含LCDR1、LCDR2和LCDR3，其序列信息详见序列表。本发明制备得到的抗体在亲和力方面有更好的表现、在体内抑制肿瘤生长的效果更好、毒副作用更小。