Umbilical cord mesenchymal stem cell for treating cerebral infarction as well as preparation method and application of umbilical cord mesenchymal stem cell

The invention belongs to the technical field of biological medicines, and particularly relates to umbilical cord mesenchymal stem cells for treating cerebral infarction as well as a preparation method and application of the umbilical cord mesenchymal stem cells. The exosome of the umbilical cord mesenchymal stem cell provided by the invention contains a fusion protein, the protein is formed by fusing a peptide of a targeted brain tissue and an exosome transmembrane protein CD63, and is anchored on the surface of the exosome, so that the exosome is ensured to have stronger blood brain barrier crossing capability, the targeting property and the activity are improved, and cerebral infarction is further treated. 本发明属于生物药物技术领域，具体涉及一种治疗脑梗的脐带间充质干细胞及其制备方法和应用。本发明提供的脐带间充质干细胞的外泌体包含有一种融合蛋白，该蛋白是由靶向脑组织的肽和外泌体跨膜蛋白CD63融合而成，并锚定在外泌体表面，从而保证外泌体具有更强的穿越血脑屏障能力，提高靶向性和活性，进一步治疗脑梗。