Compound with fused ring structure, preparation method and application thereof as well as pharmaceutical composition and application thereof
The invention relates to a fused ring structure compound, a preparation method and application thereof, and a pharmaceutical composition and application thereof. The structure of the compound with the fused ring structure is shown as a general formula I in the specification. Experiments prove that t...
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| creator | CHEN HAO AI HUIBING CAO MINJUN ZHANG KAIXIANG BI XIPING LI HONGDA |
| description | The invention relates to a fused ring structure compound, a preparation method and application thereof, and a pharmaceutical composition and application thereof. The structure of the compound with the fused ring structure is shown as a general formula I in the specification. Experiments prove that the compound casein lyase P (ClpP) with the fused ring structure has a remarkable excitation effect and can be applied to treatment of various ClpP related diseases.
本发明涉及并环结构化合物、其制备方法及其用途以及药物组合物及其用途。所述并环结构化合物，其结构如通式I所示。本发明通过实验验证，所述并环结构化合物酪蛋白裂解酶P(ClpP)有显著的激动作用，可应用于多种ClpP相关疾病的治疗。 |
| format | Patent |
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本发明涉及并环结构化合物、其制备方法及其用途以及药物组合物及其用途。所述并环结构化合物，其结构如通式I所示。本发明通过实验验证，所述并环结构化合物酪蛋白裂解酶P(ClpP)有显著的激动作用，可应用于多种ClpP相关疾病的治疗。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241001&DB=EPODOC&CC=CN&NR=118724903A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20241001&DB=EPODOC&CC=CN&NR=118724903A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN HAO</creatorcontrib><creatorcontrib>AI HUIBING</creatorcontrib><creatorcontrib>CAO MINJUN</creatorcontrib><creatorcontrib>ZHANG KAIXIANG</creatorcontrib><creatorcontrib>BI XIPING</creatorcontrib><creatorcontrib>LI HONGDA</creatorcontrib><title>Compound with fused ring structure, preparation method and application thereof as well as pharmaceutical composition and application thereof</title><description>The invention relates to a fused ring structure compound, a preparation method and application thereof, and a pharmaceutical composition and application thereof. The structure of the compound with the fused ring structure is shown as a general formula I in the specification. Experiments prove that the compound casein lyase P (ClpP) with the fused ring structure has a remarkable excitation effect and can be applied to treatment of various ClpP related diseases.
本发明涉及并环结构化合物、其制备方法及其用途以及药物组合物及其用途。所述并环结构化合物，其结构如通式I所示。本发明通过实验验证，所述并环结构化合物酪蛋白裂解酶P(ClpP)有显著的激动作用，可应用于多种ClpP相关疾病的治疗。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjcEKwjAQRHvxIOo_rHcFawX1KEHx5Ml7WdKtCaTJkmzoT_jRtupV8DQwvDczLZ4qdByyb6C3YqDNiRqI1j8gScxacqQVcCTGiGKDh47EhAZwMJDZWf2pxVCk0AIm6Mm5Mdlg7FBTlgFyoMejZN_0D3teTFp0iRbfnBXLy_murmviUFPiYcyT1OpWlof9dnfcVKfqH-YFzaNO3w</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>CHEN HAO</creator><creator>AI HUIBING</creator><creator>CAO MINJUN</creator><creator>ZHANG KAIXIANG</creator><creator>BI XIPING</creator><creator>LI HONGDA</creator><scope>EVB</scope></search><sort><creationdate>20241001</creationdate><title>Compound with fused ring structure, preparation method and application thereof as well as pharmaceutical composition and application thereof</title><author>CHEN HAO ; AI HUIBING ; CAO MINJUN ; ZHANG KAIXIANG ; BI XIPING ; LI HONGDA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118724903A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN HAO</creatorcontrib><creatorcontrib>AI HUIBING</creatorcontrib><creatorcontrib>CAO MINJUN</creatorcontrib><creatorcontrib>ZHANG KAIXIANG</creatorcontrib><creatorcontrib>BI XIPING</creatorcontrib><creatorcontrib>LI HONGDA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN HAO</au><au>AI HUIBING</au><au>CAO MINJUN</au><au>ZHANG KAIXIANG</au><au>BI XIPING</au><au>LI HONGDA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compound with fused ring structure, preparation method and application thereof as well as pharmaceutical composition and application thereof</title><date>2024-10-01</date><risdate>2024</risdate><abstract>The invention relates to a fused ring structure compound, a preparation method and application thereof, and a pharmaceutical composition and application thereof. The structure of the compound with the fused ring structure is shown as a general formula I in the specification. Experiments prove that the compound casein lyase P (ClpP) with the fused ring structure has a remarkable excitation effect and can be applied to treatment of various ClpP related diseases.
本发明涉及并环结构化合物、其制备方法及其用途以及药物组合物及其用途。所述并环结构化合物，其结构如通式I所示。本发明通过实验验证，所述并环结构化合物酪蛋白裂解酶P(ClpP)有显著的激动作用，可应用于多种ClpP相关疾病的治疗。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compound with fused ring structure, preparation method and application thereof as well as pharmaceutical composition and application thereof |
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