Compound with fused ring structure, preparation method and application thereof as well as pharmaceutical composition and application thereof

The invention relates to a fused ring structure compound, a preparation method and application thereof, and a pharmaceutical composition and application thereof. The structure of the compound with the fused ring structure is shown as a general formula I in the specification. Experiments prove that the compound casein lyase P (ClpP) with the fused ring structure has a remarkable excitation effect and can be applied to treatment of various ClpP related diseases. 本发明涉及并环结构化合物、其制备方法及其用途以及药物组合物及其用途。所述并环结构化合物，其结构如通式I所示。本发明通过实验验证，所述并环结构化合物酪蛋白裂解酶P(ClpP)有显著的激动作用，可应用于多种ClpP相关疾病的治疗。