Application of nitroreductase in synthesis of axially chiral compound

The invention discloses nitroreductase and application thereof in synthesis of an axially chiral compound, belongs to the technical field of bioengineering, and comprises nitroreductase and engineering bacteria excavated from Bacteroides fragilis, and application of the nitroreductase and the engineering bacteria in reduction of a nitro axially chiral compound to form axially chiral amine. The nitroreductase has relatively high conversion rate and selectivity in synthesis of axial chirality, is short in reaction time and simple in condition, and has a wide prospect in synthesis of axial chirality chemistry. The invention obtains the support of a national key research and development plan project (the project name is construction of a nano artificial hybrid biological system and tumor immunologic diagnosis and treatment application, and the project number is 2021YFA0909900). 本发明公开了一种硝基还原酶及在轴手性化合物合成中的应用，属于生物工程技术领域，包括从脆弱拟杆菌(Bacteroides fragilis)挖掘到的硝基还原酶，工程菌，以及在还原硝基轴手性化合物形成轴手性胺的应用，该硝基还原酶在合成轴手性中具有较高的转化率及选择性，反应时间短