Fusion protein for preventing streptococcus pneumoniae infection and application thereof

The invention relates to a fusion protein for preventing streptococcus pneumoniae infection, an immunogenic composition, a recombinant vaccine, molecular architecture design, application and the like. Starting from a protein molecule tertiary structure of ply and PhtD, creative screening is performed, a C-terminal structural domain of a ply protein and an N-terminal structural domain of a phtD protein are finally selected to construct a fusion protein, and elements such as an Fc structural domain and STABILON are further added. The fusion protein molecule can weaken tissue lesions caused by streptococcus pneumoniae infection, has good immunogenicity, has effective prevention and immune protection effects, and efficiently prevents streptococcus pneumoniae infection. The immunogenic composition, the fusion protein and the recombinant vaccine for preventing streptococcus pneumoniae infection have wide application prospects. 本发明涉及一种预防肺炎链球菌感染的融合蛋白、免疫原性组合物、重组疫苗，以及分子架构设计和应用等。本发明从ply、PhtD的蛋白分子三级结构出发，经创造性地筛选，最终选取ply蛋白