2-[2-methyl-6-(quinoline-3-yl) nicotinoyl]-N-phenylhydrazine-1-formamide derivative as well as preparation method and application thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to a 2-[2-methyl-6-(quinoline-3-yl) nicotinoyl]-N-phenylhydrazine-1-formamide derivative as well as a preparation method and application thereof. The 2-[2-methyl-6-(quinoline-3-yl) nicotinoyl]-N-phenylhydrazine-1-formamide derivative is synthesized for the first time, and the preparation method of the 2-[2-methyl-6-(quinoline-3-yl) nicotinoyl]-N-phenylhydrazine-1-formamide derivative is low in raw material cost, high in yield, simple and easy to control in reaction process, and suitable for industrial production; moreover, the derivatives have high NR4A1 protein level inhibitory activity and can be used for preparing anti-hepatoma drugs. 本发明属于药物化学领域，具体涉及2-[2-甲基-6-(喹啉-3-基)烟酰基]-N-苯肼-1-甲酰胺衍生物及制备方法和应用。本发明首次合成了2-[2-甲基-6-(喹啉-3-基)烟酰基]-N-苯肼-1-甲酰胺衍生物，且2-[2-甲基-6-(喹啉-3-基)烟酰基]-N-苯肼-1-甲酰胺衍生物的制备方法原料成本低、产率高、反应过程简单易控制，适用于工业化生产，而且该类衍生物具有高的NR4A1蛋白水平抑制活性，能够用于制备抗肝癌药物。