Preparation method of inhibitor WJ460

The invention relates to the field of organic chemistry, in particular to a preparation method of an inhibitor WJ460, which comprises the following steps: carrying out first-stage reaction on a compound as shown in a formula I and 2-anisidine in a solvent, and then adding mercaptoacetic acid to carry out second-stage reaction to obtain the inhibitor WJ460. Then removing excessive moisture in the reaction by using a water segregator under a high-temperature condition, and then adding mercaptoacetic acid to continue the reaction; the method is novel in operation method, cost-saving, green and efficient, and conforms to the concept of modern organic chemistry development. 本发明涉及有机化学领域，涉及一种抑制剂WJ460的制备方法，所述制备方法为：将式I所示化合物与2-甲氧基苯胺在溶剂中第一阶段反应后，再加入巯基乙酸进行第二阶段反应，得到所述抑制剂WJ460本发明提供的工艺合成法，先通过缩合得到中间体，然后利用分水器在高温条件下，除去反应中的多余水分，再加入巯基乙酸继续反应。该方法操作方法新颖，节省成本，绿色高效，符合现代有机化学发展的理念。