Immunogenicity enhancing mRNA vaccine compositions and related uses

The invention provides an mRNA (messenger ribonucleic acid) vaccine composition for enhancing immunogenicity and related application. Specifically, the invention provides the mRNA vaccine composition, the mRNA vaccine composition comprises an antigen mRNA and a cell factor mRNA, and the cell factor is selected from one or more cell factors in a colony stimulating factor superfamily, an interleukin family, an interferon family, a tumor necrosis factor superfamily and a chemokine receptor superfamily; preferably, the cytokines are selected from one or more of GM-CSF (granulocyte-macrophage colony-stimulating factor), IFN (interferon)-alpha 1, Cd 40 lg, Cx3cr1, IL12B (interleukin-12B), IFN-alpha 2, IFN-alpha 4, IFN-gamma and IL-12 (interleukin-12). In the composition provided by the invention, the cell factor mRNA can enhance the immunogenicity of the antigen mRNA vaccine and has a vaccine adjuvant effect. 本发明提供了一种增强免疫原性的mRNA疫苗组合物及相关应用。具体而言，本发明提供了一种mRNA疫苗组合物，其包括：抗原mRNA以及细胞因子mRNA，所述细胞因子选自集落刺激因子超家族、白介素家族、干扰素家族、肿瘤坏