Application of V9302 in preparation of medicine for treating pancreatic cancer

The invention belongs to the field of biomedicine, and particularly relates to application of V9302 in preparation of drugs for treating pancreatic cancer, it is shown that glutamine can promote proliferation, migration and invasion ability of pancreatic cancer and can up-regulate protein expression of pancreatic cancer cells KRAS, and the higher the concentration of glutamine is, the higher the protein level of pancreatic cancer cells KRAS is; the invention also shows that by adding the V9302, the expression of SLC1A5 and SLC7A5 in pancreatic cancer cells can be inhibited at the same time, and the migration, invasion and peripheral nerve infiltration capability of the pancreatic cancer cells are inhibited. Therefore, V9302 can be used for drugs for inhibiting pancreatic cancer nerve metastasis. 本发明属于生物医学领域，具体涉及V9302在制备治疗胰腺癌药物中的应用，本发明表明谷氨酰胺可促进胰腺癌的增殖、迁移和侵袭能力，可上调胰腺癌细胞KRAS蛋白表达，且谷氨酰胺浓度越高，胰腺癌细胞KRAS的蛋白水平就越高；本发明还表明通过添加V9302能够同时抑制胰腺癌细胞中SLC1A5和SLC7A5的表达，抑制胰腺癌细胞的迁移、侵袭和周围神经浸润能力。因此，V9302可用于抑制胰腺癌神经转移的药物。