Macrocyclic btk inhibitors

The present invention relates to macrocyclic compounds useful as kinase inhibitors, in particular as BTK (Bruton's Tyrosine Kinase) inhibitors, and compositions containing said compounds. Furthermore, the present invention provides methods of making the disclosed compounds and methods of using...

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Hauptverfasser:	BUCHMANN RICHARD C, STRU MBERG, JAN, G, GROBEN YUVAL, DE MAN ADRIANUS PETRUS ANTONIUS, VU-PHAM, DUY, DE WIT JOERI JOHANNES PETRUS, VAN COTT, FRANK, M ¨ 1 LLER, MICHAEL, VAN GEMERT, SIMON, P., W, PRINSEN MARTINUS BERNARDUS WILHELMUS, SIMMONS-VAN RIEL WILLEM EDUARD, VAN MEEL, YURI, GERARDUS, THEODORUS, MULDER, WILHELMUS, R
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to macrocyclic compounds useful as kinase inhibitors, in particular as BTK (Bruton's Tyrosine Kinase) inhibitors, and compositions containing said compounds. Furthermore, the present invention provides methods of making the disclosed compounds and methods of using them, e.g., as medicaments, in particular for the treatment of Bruton's tyrosine kinase (BTK) mediated disorders, such as cancer. # imgabs0 # 本发明涉及用作激酶抑制剂、特别是用作BTK(布鲁顿酪氨酸激酶)抑制剂的大环化合物和含有所述化合物的组合物。此外，本发明提供了制备所公开的化合物的方法以及使用它们的方法，例如作为药物使用的方法、特别是用于治疗布鲁顿酪氨酸激酶(BTK)介导的障碍例如癌症的方法。#imgabs0#