Preparation method of alloy catalytic cluster capable of targeting lysosome

The invention belongs to the technical field of functional biological nanomaterials, and particularly relates to preparation and functional elaboration of an alloy catalytic cluster (KCK-AuCdNCs) which can target lysosome and has high enzyme-like activity. By designing an oligopeptide sequence and d...

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Hauptverfasser: YANG WENXUAN, HUANG FANG, WEI XIAOYUN, MAO JIAN, WANG SHENMING, CHENG YIFENG, WANG XIAOJUAN, WANG ZHIRUI, MIAO XINTONG, ZHEN ZHENG, HE HUA, QIN GUANGYONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of functional biological nanomaterials, and particularly relates to preparation and functional elaboration of an alloy catalytic cluster (KCK-AuCdNCs) which can target lysosome and has high enzyme-like activity. By designing an oligopeptide sequence and doping a cadmium element, the cadmium-doped oligopeptide is synthesized by utilizing a water-phase synthesis method. The average particle size of the KCK-AuCdNCs is 1.46 +/-0.05 nm, the KCK-AuCdNCs has an absorption peak at 580 nm, the emission peak is 650 nm under excitation of 365 nm laser, and the KCK-AuCdNCs has non-scintillation fluorescence and is suitable for fluorescence labeling imaging. The compound has peroxidase activity and antioxidant capacity, cell experiments prove that the compound can be rapidly taken by cells and target lysosome, the co-localization Pearson coefficient reaches 0.921, and reactive oxygen free radicals can be efficiently removed. The preparation method is simple and low in cost, the