Golden larch bark acetic acid derivative and preparation method thereof

The invention discloses a golden larch bark acetic acid derivative and a preparation method thereof. Golden larch bark acetic acid is used as a lead compound to synthesize a series of amino acid derivatives which have a stronger inhibiting effect on expression of VEGF protein in tumor cells and reduce VEGF protein exosis. The designed and synthesized golden larch bark acetic acid derivative does not show cytotoxicity (IC50gt; it is indicated that the pseudolaric acid and the derivative thereof inhibit VEGF exogenesis in SiHa cells through cytotoxicity, and the inhibitory activity of the pseudolaric acid derivative is significantly higher than that of the lead compound pseudolaric acid. The preparation method of the compound also has the advantages of abundant raw material sources, mild reaction conditions, simple reaction process operation, cheap and easily available reagents and the like. 本发明公开了一种土荆皮乙酸衍生物及其制备方法，以土荆皮乙酸为先导化合物合成一系列对肿瘤细胞内的VEGF蛋白的表达有更强抑制作用，减少VEGF蛋白外泌的氨基酸衍生物。设计合成的土荆皮乙酸衍生物，对siHa细胞均未表现出细胞毒性(IC50>30μ