Eupatilin derivative containing piperazine structure as well as preparation method and application of eupatilin derivative

The invention belongs to the field of natural products and medicinal chemistry, and particularly relates to an eupatilin derivative containing a piperazine structure as well as a preparation method and application of the eupatilin derivative. The invention provides an eupatilin derivative containing a piperazine structure. The eupatilin derivative is a compound as shown in a formula (I) and a formula (II): # imgabs0 #. The eupatilin derivatives containing the piperazine structures and shown in the general formulas (I) and (II) have good anti-tumor activity on various tumor cell types including gastric cancer, esophageal cancer, lung cancer, liver cancer, breast cancer and the like, a new compound entity is provided for research and development of anti-tumor drugs, and the eupatilin derivatives have good application prospects. 本发明属于天然产物及药物化学领域，具体涉及一种含哌嗪类结构的异泽兰黄素衍生物及其制备方法和应用。本发明提供的含哌嗪类结构的异泽兰黄素衍生物，为式（I）及（II）所示的化合物：#imgabs0#。本发明提供的通式（I）、（II）所示的含哌嗪类结构的异泽兰黄素衍生物对多种肿瘤细胞类型包括胃癌、食管癌、肺癌、肝癌、乳腺癌在内等均具有较好的抗肿瘤活性，为抗肿瘤药物的研发提供新的