Exonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors and compositions and uses thereof

The invention relates to an exonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor as well as a composition and application thereof, in particular to a compound as shown in a formula (I), or pharmaceutically acceptable salt, stereoisomer, hydrate, deuterated substance or prodrug thereof...

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Bibliographische Detailangaben
Hauptverfasser:	WANG YITIAN, ZHANG SULIN, HUANG LIN, WU XIAOWEI, YANG RUIRUI, YANG PEILING, WANG QIANG, ZHENG MINGYUE, MENG HAIFANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to an exonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor as well as a composition and application thereof, in particular to a compound as shown in a formula (I), or pharmaceutically acceptable salt, stereoisomer, hydrate, deuterated substance or prodrug thereof, and a pharmaceutical composition containing the compound and the pharmaceutical composition and application thereof. The compound can be used as an ENPP1 inhibitor, and is used for treating and/or preventing diseases related to ENPP1 dysfunction. # imgabs0 # 本发明涉及一类外核苷酸焦磷酸酶/磷酸二酯酶1(ENPP1)抑制剂及其组合物和用途，具体地，本发明涉及式(I)所示化合物，或者其药学上可接受的盐、立体异构体、水合物、氘代物或者前药以及含有它们的药物组合物和其用途。所述化合物可以作为ENPP1抑制剂，用于治疗和/或预防与ENPP1功能障碍相关的疾病。#imgabs0#