Application of curcumin compound

The invention discloses application of curcumin compounds, and relates to the technical field of drug development. According to the application of the curcumin compound in preparation of the glutamine acyl cyclase inhibitor, the structural formula of the curcumin compound is # imgabs0, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently selected from one of H, hydroxyl and methoxyl, and at least one group of R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 is hydroxyl; r11 is H or hydroxyl; # imgabs 1 # represents a single bond or a double bond; at least one of two rings in the structural formula is a benzene ring. Hydroxyl groups on two side rings of the curcumin compound provided by the invention can be chelated with zinc ions at the bottom of a QC protein active center pocket, so that interaction is realized, good inhibitory activity is generated, and the curcumin compound can be further used for preparing a QC inhibitor. 本发明公开姜黄素类化合物的应用，涉及药物开发技术领域。姜黄素类化合物在制备谷氨酰胺酰基环化酶抑制剂中的应用，所述姜黄素类化合物的结构式为：#imgabs0#其中，R