DUAL MHC TARGETING T CELL JOINTS

Described herein are antigen binding proteins comprising a Fab domain that specifically binds to a cell surface protein of an immune cell, a first pMHC binding domain, and a second pMHC binding domain. Methods of treating cancer or viral infections with the antigen binding proteins are also described. 本文描述了抗原结合蛋白，所述抗原结合蛋白包含特异性结合至免疫细胞的细胞表面蛋白的Fab结构域、第一pMHC结合结构域和第二pMHC结合结构域。还描述了用所述抗原结合蛋白治疗癌症或病毒感染的方法。