Multivalent influenza vaccines

Disclosed are multivalent vaccines or immunogenic compositions comprising an influenza virus hemagglutinin (HA) or a ribonucleic acid molecule encoding the influenza virus hemagglutinin from a standard influenza virus strain of care; and one or more influenza virus HA identified or designed by machine learning, or one or more ribonucleic acid molecules encoding the influenza virus HA identified or designed by machine learning. Methods of using these vaccines or immunogenic compositions are also disclosed. 披露了多价疫苗或免疫原性组合物，其包含来自护理标准流感病毒株的流感病毒血凝素(HA)或编码该流感病毒血凝素的核糖核酸分子；和由机器学习鉴定或设计的一种或多种流感病毒HA，或编码该由机器学习鉴定或设计的流感病毒HA的一种或多种核糖核酸分子。还披露了使用这些疫苗或免疫原性组合物的方法。