Antibodies targeting CD274 and uses thereof

The invention relates to the fields of immunology and oncology, and relates to a CD274 (PD-L1) targeting antibody and application thereof. In particular to a PD-L1 targeting nano antibody or an antigen binding fragment thereof, a nucleic acid molecule for coding the nano antibody or the antigen bind...

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Bibliographische Detailangaben
Hauptverfasser:	LIN CHAOLONG, HWANG SEUNG-HO, LI SHAOPENG, TANG JIXIAN, LOU RUI, TENG WENZHONG, ZHANG JUN, XIA, NINGSHAO, LUO WENXIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to the fields of immunology and oncology, and relates to a CD274 (PD-L1) targeting antibody and application thereof. In particular to a PD-L1 targeting nano antibody or an antigen binding fragment thereof, a nucleic acid molecule for coding the nano antibody or the antigen binding fragment thereof, and a host cell comprising the same. The invention also relates to a bispecific antibody, a conjugate and a pharmaceutical composition containing the nano antibody or the antigen binding fragment thereof, and application of the bispecific antibody, the conjugate and the pharmaceutical composition in tumor treatment. 本发明涉及免疫学及肿瘤学领域，涉及靶向CD274(PD-L1)的抗体及其用途。具体而言涉及靶向PD-L1的纳米抗体或其抗原结合片段，编码所述纳米抗体或其抗原结合片段的核酸分子及包含其的宿主细胞。本发明还涉及包含所述纳米抗体或其抗原结合片段的双特异性抗体、缀合物和药物组合物，以及它们在治疗肿瘤中的用途。