Polypeptide for inhibiting replication of herpes virus and application thereof
The invention discloses a polypeptide for inhibiting herpes virus replication and application thereof, and belongs to the field of biological medicine. A polypeptide capable of specifically interfering the interaction of OTUD4 and USP7, remarkably reducing the RTA protein level and inhibiting splitt...
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Zusammenfassung: | The invention discloses a polypeptide for inhibiting herpes virus replication and application thereof, and belongs to the field of biological medicine. A polypeptide capable of specifically interfering the interaction of OTUD4 and USP7, remarkably reducing the RTA protein level and inhibiting splitting replication of the herpes virus is screened, the amino acid sequence of the polypeptide is VNQSASQSSN, the polypeptide containing the amino acid sequence can be used for preparing anti-herpes virus drugs or drugs for preventing and treating herpes virus infection, the herpes virus is gamma herpes virus, and the polypeptide can be used for preparing anti-herpes virus drugs or drugs for preventing and treating herpes virus infection. Comprising KSHV and MHV68.
本发明公开了一种抑制疱疹病毒复制的多肽及其应用,属于生物医药领域。本发明筛选到一条能够特异性干扰OTUD4和USP7相互作用、显著降低RTA蛋白水平、抑制疱疹病毒裂解复制的多肽,其氨基酸序列为VNQSASQSSN,含该氨基酸序列的多肽能够用于制备抗疱疹病毒药物或防治疱疹病毒感染的药物,其中所述的疱疹病毒为γ疱疹病毒,包括KSHV、MHV68。 |
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