Preparation method and application of Cyclo (Pro-Val)

The invention belongs to the technical field of chemical analysis, and particularly relates to a preparation method and application of Cyclo (Pro-Val). In order to solve the problems that raw materials are not easy to obtain and a preparation process is complicated in an existing Cyclo (Pro-Val) pre...

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Bibliographische Detailangaben
Hauptverfasser: SU JIAN, YANG ZIDAN, LIAO QINJIAN, GUO YAN, HU JIAO, LI SONGBAI, LUO ZHU, ZHENG JIA, WANG FANG, ZHOU HANLING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of chemical analysis, and particularly relates to a preparation method and application of Cyclo (Pro-Val). In order to solve the problems that raw materials are not easy to obtain and a preparation process is complicated in an existing Cyclo (Pro-Val) preparation method, various separation technologies such as organic solvent precipitation, macroporous resin column chromatography, gel column chromatography and preparative chromatography are combined, and Cyclo (Pro-Val) with the purity of 95% or above is separated from yellow water with complicated components for the first time. The preparation method disclosed by the invention is simple and convenient, low in cost and high in product purity, and develops a resource utilization way of the yellow water. In addition, by evaluating the inhibitory activity of the Cyclo (Pro-Val) on angiotensin converting enzyme (ACE), the invention provides a new application of the Cyclo (Pro-Val) in the aspect of assisting the develop