Piperidine-substituted benzoic acid compound as well as medicinal composition and application thereof

The invention discloses a compound as shown in a formula I, a stereoisomer or pharmaceutically acceptable salt thereof, and particularly provides a piperidine substituted benzoic acid compound, a pharmaceutical composition and application thereof, and the compound has good inhibitory activity on com...

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Bibliographische Detailangaben
Hauptverfasser:	MAO YANJIA, CHEN LIKUO, TANG ZHIWEI, CHEN CHEN, WANG HONGBO, WU XUESONG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses a compound as shown in a formula I, a stereoisomer or pharmaceutically acceptable salt thereof, and particularly provides a piperidine substituted benzoic acid compound, a pharmaceutical composition and application thereof, and the compound has good inhibitory activity on complement factor B; furthermore, the compound can be used for treating paroxysmal sleep hemoglobinuria, C3 glomerulopathy, IgA nephropathy, age-related macular degeneration (AMD) and other diseases. # imgabs0 # 本发明公开了一种如式I所示化合物、其立体异构体或其药学上可接受的盐，具体地，提供了一种哌啶取代的苯甲酸类化合物、其药用组合物及其应用，该类化合物对补体因子B具有很好的抑制活性；进一步地，可用于治疗阵发性睡眠性血红蛋白尿症、C3肾小球病、IgA肾病、年龄相关性黄斑变性(AMD)等疾病。#imgabs0#