Synthetic method of epigallocatechin gallate

The invention discloses a synthesis method of epigallocatechin gallate, which comprises the following steps: in an inert protective atmosphere, in the presence of a supported nickel catalyst and an alkali reagent, carrying out hydrogenation debenzylation reaction on a benzyl protection precursor compound 1 in a solvent to obtain the epigallocatechin gallate (-)-EGCG. The supported nickel which is simple, easy to obtain and low in cost is adopted as the catalyst, and cost is reduced; the nickel-loaded catalyst can be removed through simple filtration operation, and the product is simple to separate and purify; the reaction conditions are mild; the (-)-EGCG is high in yield and high in purity. # imgabs0 # 本发明公开了一种表没食子儿茶素没食子酸酯的合成方法，包括下述的步骤：在惰性保护气氛下，在负载镍催化剂和碱试剂的存在下，使苄基保护前体化合物1在溶剂中进行加氢脱苄基反应，得到表没食子儿茶素没食子酸酯(-)-EGCG。本发明采用简单易得且廉价的负载镍作为催化剂，降低成本；负载镍催化剂通过简单过滤操作可除去，产物分离纯化简单；反应条件温和；(-)-EGCG产率高、纯度高。#imgabs0#