Novel split-ring iridoid compound as well as preparation method, pharmaceutical composition and application thereof

The invention belongs to the technical field of medicines, and particularly discloses a novel split-ring iridoid compound as well as a preparation method, a pharmaceutical composition and application thereof. The split-ring iridoid compound (+/-)-Cornuscone provided by the invention has not been reported at present. Experimental results show that the split-ring iridoid compound provided by the invention has remarkable anti-inflammatory activity on RAW 264.7 cells induced by lipopolysaccharide, is obviously superior to that of a positive drug indometacin, can be used for developing drugs for treating various inflammation-related diseases, and has wide application prospects. Comprise but are not limited to arthritis, conjunctivitis, pneumonia, hepatitis, nephritis, enterogastritis, metabolic syndrome, diabetes, cancer and the like. 本发明属于医药技术领域，具体公开了一种新型裂环环烯醚萜类化合物及其制备方法、药物组合物和应用。本发明所提供的裂环环烯醚萜类化合物(±)-Cornuscone目前尚未见报道。实验结果表明，本发明所提供的裂环环烯醚萜类化合物对脂多糖诱导的RAW 264.7细胞具有显著的抗炎活性，明显优于阳性药吲哚美辛，可用于开发治疗各种炎症相关疾病的药物，包括但不限于关节炎、结膜炎