Novel chalcone compound as well as preparation method, pharmaceutical composition and application thereof

The invention discloses a novel chalcone compound as well as a preparation method, a pharmaceutical composition and application thereof, and belongs to the technical field of medicines, and the chalcone compound (+/-)-Lupulusone A provided by the invention has not been reported at present. Experimental results show that the chalcone compound provided by the invention has remarkable anti-inflammatory activity on RAW 264.7 cells induced by lipopolysaccharide, is obviously superior to a positive drug dexamethasone, and can be used for developing drugs for treating various inflammation-related diseases, including but not limited to pneumonia, hepatitis, nephritis, arthritis, conjunctivitis, enterogastritis, metabolic syndrome, diabetes mellitus, cancer and the like. 本发明公开了一种新型查尔酮类化合物及其制备方法、药物组合物和应用，属于医药技术领域，本发明所提供的查尔酮类化合物(±)-Lupulusone A目前尚未见报道。实验结果表明，本发明所提供的查尔酮类化合物对脂多糖诱导的RAW 264.7细胞具有显著的抗炎活性，明显优于阳性药地塞米松，可用于开发治疗各种炎症相关疾病的药物，包括但不限于肺炎、肝炎、肾炎、关节炎、结膜炎、肠胃炎、代谢综合征、糖尿病、癌症等。