Preparation method and application of aptamer-containing HA/betaTCP scaffold material

The invention relates to a preparation method of an aptamer-containing HA/beta TCP scaffold material and application of the aptamer-containing HA/beta TCP scaffold material prepared by the method in promotion of bone repair. According to the method disclosed by the invention, the nucleic acid aptamer is stably connected to hydroxyapatite/beta tricalcium phosphate, can specifically capture MSC and EPC on the surface of a material, realizes selective enrichment, can be applied to a clinical bone defect repair process, namely can capture two cells in situ in a bone defect, can achieve an osteogenesis and vascularization coupling effect of bone defect repair, and has a good application prospect. The bone repair is effectively promoted. 本发明涉及一种含核酸适配体的HA/βTCP支架材料的制备方法，以及用本发明所述方法制备的含核酸适配体的HA/βTCP支架材料在促进骨修复中的应用。根据本发明所述方法，核酸适配体稳定的连接在羟基磷灰石/β磷酸三钙上，并且能于材料表面特异性捕获MSC和EPC，实现选择性的富集，可应用于临床骨缺损修复过程，暨能在骨缺损原位捕获两种细胞，可以达到骨缺损修复的成骨成血管偶联作用，有效促进骨修复。