Hyaluronic acid coated aminated silicon dioxide particle carrier for delivering probiotics and preparation method and application of suspension of hyaluronic acid coated aminated silicon dioxide particle carrier

The invention belongs to the field of nano biological medicines, and relates to a preparation method and application of a carrier and suspension of hyaluronic acid coated aminated silicon dioxide particles for delivering probiotics. The aminated silicon dioxide can effectively interact with negative charges on the surfaces of the probiotics through positive charges on the surfaces of the aminated silicon dioxide, and carboxyl groups in the hyaluronic acid react with the aminated silicon dioxide to form stable amido bonds, so that the probiotics obtain a hyaluronic acid coated aminated silicon dioxide carrier (shell); the probiotics are protected from being invaded by external adverse factors, so that intestinal delivery of the probiotics is realized. 本发明属于纳米生物医药领域领域，涉及一种透明质酸包覆氨基化二氧化硅颗粒递送益生菌的载体及混悬液的制备方法和应用。氨基化二氧化硅通过其表面正电荷能够有效与益生菌表面负电荷相互作用，并且透明质酸中羧基与氨基化二氧化硅反应，形成稳定的酰胺键，从而益生菌获得一个透明质酸包覆氨基化二氧化硅载体(外壳)，保护益生菌免受外界不利因素的侵害，以实现益生菌的肠道递送。