Recombinant helicobacter pylori vaccine as well as preparation method and application thereof

The invention discloses a recombinant helicobacter pylori vaccine as well as a preparation method and application thereof. The recombinant helicobacter pylori vaccine comprises a fusion antigen and an adjuvant, the fusion antigen is a fusion protein containing a helicobacter pylori antigen protein and an immune cell factor, and the adjuvant is an intracellular metabolite of BCG-bacteria thalli. The vaccine provided by the invention has the beneficial effects that the fusion protein containing the helicobacter pylori antigen protein and the immune cell factor is taken as the fusion antigen for the first time, and the intracellular metabolite of the BCG bacteria is taken as the adjuvant. The fusion antigen has natural protein activity, can generate excellent immunogenicity, and can initiate effective anti-helicobacter pylori immune response in immune individuals. After the fusion antigen is further combined with an adjuvant, a more efficient immunoreaction aiming at the helicobacter pylori antigen can be excite