Application of circRNA0001220 inhibitor in preparation of medicine for preventing and treating diabetic retinopathy

The invention discloses application of an inhibitor of circRNA0001220 in preparation of a medicine for preventing and treating diabetic retinopathy, and belongs to the technical field of biological medicines, and circRNAID of a reference sequence of the circRNA0001220 in a circBase database is nucirc0001220; and the inhibitor is siRNA (small interfering Ribonucleic Acid) for silencing the circRNA0001220. The application proves that circRNA0001220 can be used as a therapeutic target of diabetic retina mutation for the first time, silence circRNA0001220, inhibition of MDM2 oncogene and promotion of p53 anticancer gene are realized, the effect of preventing and treating diabetic retina mutation is realized through an MDM2/p53 pathway, and a new therapeutic approach is provided for the disease. 本发明公开了circRNA_0001220的抑制剂在制备防治糖尿病视网膜病变的药物中的应用，属于生物医药技术领域，所述circRNA_0001220的参考序列在circBase数据库的circRNAID为mmu_circ_0001220；所述抑制剂为沉默所述circRNA_0001220的siRNA。本发明首次证实circRNA_0001220可作为糖尿病视网膜突变的治疗靶点，沉默circRNA_0001220，抑制MDM2癌基因和促进p5