Olaparil solid dispersion and pharmaceutical composition thereof

The invention relates to an olaparil solid dispersion as well as a pharmaceutical composition, a preparation method and application thereof. The solid dispersion can effectively improve the crushing characteristic, is less in fine powder, high in yield, good in safety, less in adsorption, diffusion and loss and strong in machinability, and greatly reduces the risk of fire or explosion. The saturation solubility is high; recrystallization is effectively inhibited, and the drug stability is improved; the dissolution speed is high, and the bioavailability is high; the method is simple in process, low in cost, high in efficiency, controllable in quality and suitable for industrial production. 本发明涉及一种奥拉帕利固体分散体及其药物组合物、制备方法和用途,所述固体分散体可有效改善粉碎特性，细粉少，收率高，安全性好，大大减少着火或爆炸风险，吸附、扩散、损失少，可加工性强；饱和溶解度高；有效抑制重结晶，改善药物稳定性；溶出快，生物利用度高；工艺简单,成本低，效率高，质量可控,适用于工业化生产。